This study that observes the neurobiological basis of chiropractic manipulative treatment of the spine in the care of major depression
Conclusion:
“Major depression may depend largely on imbalances in autonomic nervous system activity. All symptoms of depression, such as high cortisol, high adrenalin, insomnia, agitation and anxiety, can be attributed to excessive activity of the sympathetic system. Furthermore, neuroendocrine factors like dopamine, BDNF and NGF have roles in the pathophysiology of MDD. Although not yet definitely confirmed, chiropractic therapy and vagal nerve stimulation may possibly regulate the autonomic nervous system through activation of the parasympathetic nervous system, reduction of sympathetic nervous system activity, and synthesis of neuroendocrine factors. In this review we show evidence that MDD may be a symptom of autonomic imbalance and that chiropractic manipulation, spinal manipulative therapy and vagal nerve stimulation, which elicit sympathetic and parasympathetic responses, may improve autonomic imbalance and the symptoms of MDD.”
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Citation:
Kiani, A. K., Maltese, P. E., Dautaj, A., Paolacci, S., Kurti, D., Picotti, P. M., & Bertelli, M. (2020). Neurobiological basis of chiropractic manipulative treatment of the spine in the care of major depression. Acta bio-medica : Atenei Parmensis, 91(13-S), e2020006. https://doi.org/10.23750/abm.v91i13-S.10536